Clostridium difficile (PCR Control)
Purified DNA of Clostridium difficile to be used to control in vitro diagnosis techniques based on nucleic acid amplification.
|Product||Clostridium difficile (PCR Control)|
|Manufacturer||Vircell Microbiologists (Spain)|
|Technique||Amplirun DNA Control|
|Quantity||± 12.500 copies per µl, once reconstituted in 100 µl sterile bidistilled water|
Clostridium difficile is a spore-forming, Gram-positive anaerobic bacillus that produces two exotoxins: toxin A and toxin B. It is a common cause of antibiotic-associated diarrhea. In many healthy children under the age of 1 year, as well as in a small percentage of the adult population, C. difficile bacteria naturally reside in the gut and are shed in feces. The primary mode of C. difficile transmission resulting in disease is personto- person spread through the fecal-oral route, either by direct contact or through spore-contaminated objects, principally within inpatient healthcare facilities. When patients treated with broad-spectrum antibiotics, whose normal gut flora has been destroyed, are infected with spores, their gut becomes overrun with C. difficile. The clinical manifestations of infection with toxin-producing strains of C. difficile range from symptomless carriage, to mild or moderate diarrhea, to fulminant and sometimes fatal pseudomembranous colitis.