RPR (Rapid Plasma Reagin) test for Syphilis (Rapid Test)

The RPR (Rapid Plasma Reagin) test is a nontreponemal assay for detecting anti-lipoidal antibodies in serum or plasma. This assay is currently being used globally with great success. It offers laboratories a very cost-effective method to test for syphilis without requiring any other laboratory equipment.

This test is mostly performed for three reasons:

as a screening method which is then confirmed with another treponema specific assay (TPPA etc.)

To confirm a screening which has been performed with a treponema specific test (TPPA etc.)

To follow up on treatment by performing titers (1:2, 1:4, 1:8 etc.) on samples during treatment.

The RPR test is based on a reagent containing antigen coated particles. If antibodies to this antigen are present in a sample the particles will flocculate.