T-SPOT.CMV (ELISPOT)

CYTOMEGALOVIRUS AND THE ROLE OF T CELL IMMUNITY

Cytomegalovirus (CMV) is an opportunistic virus and common cause of morbidity and mortality in solid organ and hematopoietic stem cell transplantation patients. T cell immunity against CMV is an important factor in maintaining viral latency and reducing susceptibility to disease. Routine monitoring of an individual’s CMV-specific T cell response may assist evaluation of patients at risk of CMV disease and guide antiviral prophylaxis management.

HARNESSING THE POWER OF T CELLS

The proprietary T-SPOT technology, derived from the ELISPOT platform, measures immune cell responses at a single cell level. The technology detects T cell activation through cytokine release to assess the patient’s immune system.

THE T-SPOT.CMV TEST

The T-SPOT.CMV test uses this T-SPOT technology to assess a patient’s level of anti-CMV cell-mediated immunity by stimulating the circulating immune cells with CMV-specific antigens.